Purpose: The main aim of the article was to present the possibilities of improving the
definition of orphan therapy implementation projects using the P5 GPM model in the context
of reimbursement decisions.
Design/Methodology/Approach: Theoretical research aimed at verifying the applicability of
the P5 model in the practice of managing the implementation of orphan therapies. In the first
part, the authors presented the essence of defining the project. Then, the background for the
implementation of orphan therapies has been presented.
Findings: The article presents the long-term impact relating to the limitation of the
development of innovation and cooperation, as well as competences of the medical staff and
the medical environment, exclusion of the patient and his family from the labour market, the
increase in logistics costs related to attempts to reach the treatment, which has an impact on
the natural environment. All of this results in a reduction in national welfare. The authors
indicated that the use of the P5 model allows for a comprehensive analysis of the
environment of orphan therapy implementation projects both in the short and long term,
linking them with the goals of sustainable development, which in turn will ensure the correct
definition of the project and making investment decisions.
Practical Implications: Possibility to use the concept in the health technology assessment
process for the purposes of the reimbursement decision, taking into account the sustainable
development goals. The P5 model can be helpful in defining these types of projects.
Originality/Value: A look at the logic of intervention in case of reimbursement of rare
disease therapies from the perspective of the SDGs. Indication of the broad long-term impact
of the project from the point of view of all its stakeholders. The considerations presented in the article constitute an introduction to empirical research, primarily in the form of case-
studies